… and E3 ubiquitin ligases, they can target a series of receptor … The mouse antihuman cCbl
monoclonal antibody was … genes also inhibited matrix degradation, and cells transfected …

… the ubiquitin-proteasome pathway to degrade targeted proteins, … small molecules or many
antibodies. The PROTAC process is … , we used VHL E3 ubiquitin ligase to decompose the AR). …

… used to target quality control sorting receptors to the ER membrane … type E3 ubiquitin ligases,
Hrd1p and Doa10p, have been implicated in the degradation of every studied ubiquitinated …

… of a family of IgSF inhibitory receptors an d Blood 2006, 108 (… activation by targeting TAB2
and TAB3 for degradation Nature … and bispecifie monoclonal antibodies 38 Nature Medicine …

… can be coupled to receptor degradation as a mechanism to … to form a dimeric RING finger
E3 ubiquitin ligase. Several lines of … Besides targeting the receptors, proteasomal degradation …

… (lysosometargeting chimaeras)[11],AbTAC (antibody-based … )[13]和KineTAC (cytokine
receptortargeting chimeras)[14]等… cytokine receptor-targeting chimeras for targeted degradation …

… cancer based on targeted degradation of oncogenic proteins. … 剂(selective androgen receptor
modular, SARM)和E3连接酶小鼠… Targeting the von hippel-lindau E3 ubiquitin ligase using …

… degradation of toxic protein aggregates. We describe Proteolysis-Targeting Chimera and
related technologies for the targeted … of an antibody or small molecule, which binds to receptors …

… the two major protein degradation systems in mammalian cells: ubiquitin-proteasome system
… 结合细胞表面溶酶体靶向受体(Lysosome-targeting receptors,LTRs) 和跨膜蛋白胞外区段的…

… PROTAC works by recruiting an E3 ubiquitin ligase to a … This allows for the targeted
degradation of diseasecausing … Phosphorylation-specific antibodies: Antibodies that specifically …